UPLC-MS/MS法测定化妆品中丙烯酰胺的不确定度评定

doi:10.3969/j.issn.1000-1158.2021.08.19

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摘要采用超高效液相色谱-串联质谱法(UPLC-MS/MS)测定了化妆品中丙烯酰胺含量,并对其进行了不确定度评定。根据 JJF 1059.1—2012《测量不确定度评定与表示》建立测定化妆品中丙烯酰胺含量的计量学数学模型,分析和量化各不确定度分量。采用该方法检测的化妆品中丙烯酰胺的合成不确定度为0.033mg/kg,扩展不确定度为0.066mg/kg。实验测定的化妆品中丙烯酰胺含量结果为(0.502±0.066)mg/kg(k=2,置信概率P=95%)。评定结果表明,实验的不确定度主要由标准溶液配制和标准曲线拟合引入。

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	曹海荣
	薛晓康
	李晓宇

关键词 ：计量学, 丙烯酰胺, 化妆品组分检测, 超高效液相色谱-串联质谱法, 不确定度评定

Abstract：The content of acrylamide in cosmetics was determined by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC MS / MS), and the uncertainty was evaluated. According to JJF 1059.1—2012 “Evaluation and Expression of Uncertainty in Measurement”, a metrological model for determination of acrylamide residues in cosmetics was established. And each component of uncertainty in the whole measuring process was analyzed and quantified. The combined uncertainty in the determination of acrylamide in cosmetics was 0.033mg/kg and the expanded uncertainty was 0.066mg/kg. The content of acrylamide in cosmetics was (0.502±0.066)mg/kg (k=2, confidence interval P=95%). The uncertainty of the method was mainly caused by standard solution preparation and calibration fitting.

Key words： metrology acrylamide cosmetic ingredients testing UPLC-MS/MS uncertainty evaluation

收稿日期: 2019-04-24 发布日期: 2021-08-20

PACS:

TB99

基金资助:上海市化学品公共安全工程技术研究中心项目(18DZ2280700)

通讯作者: 李晓宇(1989-),男,河北石家庄人,上海化工研究院有限公司工程师,主要从事化学品定性分析和含量测试的研究工作。Email: lxy@ghs.cn E-mail: lxy@ghs.cn

作者简介: 曹海荣(1995-),女,山西柳林人,上海应用技术大学和上海化工研究院联合培养研究生,主要研究方向为分析化学与检测、化妆品中禁用物质检测。Email: 2453833328@qq.com

引用本文:

曹海荣,薛晓康,李晓宇. UPLC-MS/MS法测定化妆品中丙烯酰胺的不确定度评定[J]. 计量学报, 2021, 42(8): 1101-1109.
CAO Hai-rong,XUE Xiao-kang,LI Xiao-yu. Uncertainty Evaluation in Determination of Acrylamide Residues in Cosmetics by UPLC-MS/MS. Acta Metrologica Sinica, 2021, 42(8): 1101-1109.

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http://jlxb.china-csm.org:81/Jwk_jlxb/CN/10.3969/j.issn.1000-1158.2021.08.19 或 http://jlxb.china-csm.org:81/Jwk_jlxb/CN/Y2021/V42/I8/1101

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