肿瘤细胞外泌体的生物学功能及其检测方法研究进展

doi:10.3969/j.issn.1000-1158.2023.06.23

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摘要外泌体是一类细胞分泌的微小囊泡,其中包含蛋白质、脂质和核酸等重要的生物活性物质。外泌体作为细胞间通讯的重要载体,直接参与机体内肿瘤的发生、发展进程,通过影响肿瘤微环境,进而介导肿瘤细胞的生长和迁移。由于外泌体具有特殊的生理功能,近年来,将其作为重大疾病治疗载体和生物标志物的研究日益增加,针对外泌体的检测方法也得到不断发展。对肿瘤细胞外泌体的生物学功能和检测的近期相关研究进行系统综述,并对检测方法的发展趋势加以展望。

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	宋雨蒙
	翟睿
	雷喜梅
	楚占营
	朱曼曼
	樊小雪
	叶子弘
	戴新华
	方向

关键词 ：计量学, 外泌体, 肿瘤, 生物学功能, 检测方法

Abstract：Exosomes are tiny vesicles secreted by cells, which contain important biologically active substances such as proteins, lipids, and nucleic acids. As an important carrier of cell-to-cell communication, exosomes directly participate in the occurrence and development of tumors in the body, and by affecting the tumor microenvironment, they mediate the growth and migration of tumor cells. Due to the special physiological functions of exosomes, in recent years, there has been an increasing number of studies using them as treatment vectors and biomarkers for major diseases, and the detection methods for exosomes have also been continuously developed. A systematic review was conducted on the recent research of the biological functions and detection of exosomes from tumor cells, and the development trend of detection methods was prospected.

Key words： metrology exosome;tumor;biological function;detection method

收稿日期: 2021-09-06 发布日期: 2023-06-25

PACS:

TB99

基金资助:国家重点研发计划(2018YFF0212503,2016YFF0200504,2017YFF0106001);国家自然科学基金(21927812);中国计量科学研究院研究项目(AKYZD1907, AKY1955, AKY1941, AKY1934)

通讯作者: 叶子弘(1975-),女,浙江衢州人,中国计量大学教授,主要从事生物计量和生物互作方面的研究。Email: zhye@cjlu.edu.cn E-mail: zhye@cjlu.edu.cn

作者简介: 宋雨蒙(1998-),女,江苏泰州人,中国计量大学在读研究生,主要研究方向为外泌体蛋白质组学。Email: 1351060844@qq.com

引用本文:

宋雨蒙,翟睿,雷喜梅,楚占营,朱曼曼,樊小雪,叶子弘,戴新华,方向. 肿瘤细胞外泌体的生物学功能及其检测方法研究进展[J]. 计量学报, 2023, 44(6): 992-999.
SONG Yu-meng,ZHAI Rui,LEI Xi-mei,CHU Zhan-ying,ZHU Man-man,FAN Xiao-xue,YE Zi-hong,DAI Xin-hua,FANG Xiang. Advances in the Biological Effects of Exosomes on Tumors and Their Detection Methods. Acta Metrologica Sinica, 2023, 44(6): 992-999.

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http://jlxb.china-csm.org:81/Jwk_jlxb/CN/10.3969/j.issn.1000-1158.2023.06.23 或 http://jlxb.china-csm.org:81/Jwk_jlxb/CN/Y2023/V44/I6/992

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