化妆品中新补骨脂异黄酮、补骨脂二氢黄酮、补骨脂素和异补骨脂素含量的测量不确定度评定

doi:10.3969/j.issn.1000-1158.2021.08.18

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摘要用高效液相色谱法测定化妆品中新补骨脂异黄酮、补骨脂二氢黄酮、补骨脂素和异补骨脂素含量,建立数学模型,分析检测过程中不确定度的来源,给出量化结果,得到标准不确定度和扩展不确定度。结果表明,当取95%置信概率,包含因子k为2,被测样品中新补骨脂异黄酮、补骨脂二氢黄酮、补骨脂素和异补骨脂素的含量分别为42.61μg/g、44.04μg/g 、42.94μg/g和41.90μg/g时,相应的扩展不确定度为1.65μg/g、1.82μg/g、1.66μg/g和1.61μg/g。分析了测量不确定度的主要来源,并提出了改进建议。

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关键词 ：计量学, 化妆品组分检测, 新补骨脂异黄酮, 补骨脂二氢黄酮, 补骨脂素, 异补骨脂素, 不确定度

Abstract：Uncertainties from the determination procedure of neobavaisoflavone, bavachin, psoralen and lsopsoralen in cosmetics by high performance liquid chromatography (HPLC) were assessed. The mathematical model was established, and each source and uncertainty component were analyzed. The standard uncertainty and expanded uncertainty were reported at last. The results showed that the expanded uncertainties were 1.65μg/g, 1.82μg/g, 1.66μg/g and 1.61μg/g (95% confidence level, k=2), when the content of neobavaisoflavone, bavachin, psoralen and lsopsoralen in cosmetics were 42.61μg/g, 44.04μg/g, 42.94μg/g and 41.90μg/g. The main sources for the uncertainty were discussed, and suggestions for improvement were also introduced.

Key words： metrology cosmetic ingredients testing neobavaisoflavone bavachin psoralen lsopsoralen uncertainty

收稿日期: 2019-04-09 发布日期: 2021-08-20

PACS:

TB99

通讯作者: 黄炯力(1984-),陕西宝鸡人,西安计量技术研究院高级工程师,主要从事计量技术分析研究。Email: 654104281@qq.com E-mail: zhenxia27@126.com

作者简介: 范菲(1983-),女,河南孟县人,西安市食品药品检验所副主任药师,主要从事药物分析和化妆品分析研究。Email: zhenxia27@126.com

引用本文:

范菲,黄炯力,安庆,崔颖,朱清. 化妆品中新补骨脂异黄酮、补骨脂二氢黄酮、补骨脂素和异补骨脂素含量的测量不确定度评定[J]. 计量学报, 2021, 42(8): 1094-1100.
FAN Fei,HUANG Jiong-li,AN Qing,CUI Ying,ZHU Qing. Evaluation of Measurement Uncertainty in the Determination of Psoralen, Lsopsoralen, Neobavaisoflavone and Bavachin in Cosmetics. Acta Metrologica Sinica, 2021, 42(8): 1094-1100.

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http://jlxb.china-csm.org:81/Jwk_jlxb/CN/10.3969/j.issn.1000-1158.2021.08.18 或 http://jlxb.china-csm.org:81/Jwk_jlxb/CN/Y2021/V42/I8/1094

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