生物标志物胍基乙酸与肌酸的研究进展

doi:10.3969/j.issn.1000-1158.2023.10.21

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摘要胍基乙酸(guanidineacetic acid, GAA)和肌酸(creatine, CRE)作为人体内源性物质,其自身及相关代谢物担负着重要的生理功能,含量和组成均对人体的组织和器官产生影响。GAA是CRE的前体,而CRE可以在肌酸激酶的作用下与腺嘌呤核苷三磷酸结合形成磷酸肌酸,磷酸肌酸是人体内能量储存与利用的物质基础。此外,GAA和CRE也与诸多遗传代谢疾病的发生与发展相关,对其进行快速检测在这类疾病的早期发现与治疗中至关重要。系统综述了目前已知的与GAA和CRE相关的疾病及其治疗方法,也对生物样本中GAA与CRE的现代检测方法加以总结与评述,并展望其未来的可能发展趋势。

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	刘若祎
	谢洁
	乔晓婷
	江游
	黄泽建
	戴新华
	方向
	叶子弘

关键词 ：计量学, 胍基乙酸, 肌酸, 肌酸缺乏综合症

Abstract：Guanidineacetic acid (GAA) and creatine (CRE), as endogenous substances of human, themselves and their related metabolites are responsible for important physiological functions, and their content and composition have an impact on human tissues and organs. GAA is the precursor of CRE, and CRE can combine with adenosine triphosphate under the action of creatine kinase to form creatine phosphate, which is the material basis for energy storage and utilization in human body. In addition, GAA and CRE are also related to the occurrence and progression of many genetic metabolic diseases, and their rapid detection is essential for the early detection and treatment of such diseases. The currently known diseases correlated with GAA and CRE and their treatment methods are reviewed systematically. The modern detection methods of GAA and CRE in biological samples are also summarized and reviewed, and their possible developmental trends in the future are prospected.

Key words： metrolog gyuanidineacetic acid creatine creatine deficiency syndrome

收稿日期: 2021-12-27 发布日期: 2023-10-10

PACS:

TB99

基金资助:国家重点研发计划(2020YFF01014603);中国计量科学研究院基本业务费(AKY1934)

通讯作者: 叶子弘(1975-),浙江衢州人,中国计量大学教授,主要从事生物计量与生物互作方面的工作。Email: zhye@cjlu.edu.cn E-mail: irisroy@icloud.com

作者简介: 刘若祎(1995-),湖北荆门人,中国计量大学、中国计量科学研究院硕士研究生,主要研究方向为质谱新技术新方法与生物计量。Email: irisroy@icloud.com

引用本文:

刘若祎,谢洁,乔晓婷,江游,黄泽建,戴新华,方向,叶子弘. 生物标志物胍基乙酸与肌酸的研究进展[J]. 计量学报, 2023, 44(10): 1631-1638.
LIU Ruo-yi,XIE Jie,QIAO Xiao-ting,JIANG You,HUANG Ze-jian,DAI Xin-hua,FANG Xiang,YE Zi-hong. Research Progress on the Detection Methods of Guanidinoacetic Acid and Creatine in Biological Samples. Acta Metrologica Sinica, 2023, 44(10): 1631-1638.

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