基于脑电非线性动力学特征探究TEAS内关穴对焦虑的影响

doi:10.3969/j.issn.1000-1158.2022.01.21

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摘要基于脑电非线性动力学特征,探究经皮穴位电刺激(TEAS)内关穴对焦虑的影响及其机制。实验选取12位焦虑受试者随机分为TEAS内关穴干预组(穴位组)和TEAS非穴位干预组(非穴位组),分别采集电刺激前后各组受试者脑电数据,提取脑电信号的特征近似熵(ApEn)与关联维数(D;2),分析大脑复杂度的变化,同时比较电刺激前后焦虑自评量表(SAS)评分变化进行效果评定。实验表明,电刺激后穴位组的SAS量表评分比刺激前显著降低,且各个脑区的复杂度均存在下降趋势,脑电信号的ApEn在AF3、F7、F3、P7、F8、F4、AF4通道具有显著性差异(p<0.05),D;2在AF3、F3、Fc5、T7、P7、F8、F4、AF4通道存在显著性差异(p<0.05);但非穴位组量表评分及参数值均无明显变化。进而得出TEAS内关穴能有效缓解焦虑情绪,并改善各脑区的复杂度,尤以左、右额区及左右颞区最为明显。

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	樊凤杰
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关键词 ：计量学;脑电信号, 内关穴, 焦虑, 经皮穴位电刺激, 近似熵, 关联维数

Abstract：To explore the effect of Transcutaneous electrical acupoint stimulation (TEAS) Neiguan on anxiety and its possible mechanisms based on the nonlinear dynamic characteristics of EEG. Twelve anxiety patients are randomly divided into two groups. The acupuncture group receives TEAS on Neiguan point, the non-acupuncture group receives TEAS on non-acupuncture point. the EEG data is collected before and after the experiment. EEG characteristics, approximate entropy (ApEn) and correlation dimension (D;2), are extracted and analyzed to study the change of complexity, and use the change of SAS to assess the effect. Experimental results showed that the scale scores are significantly reduced, and the complexity assume a downward trend in the acupuncture group. The ApEn data are decline significantly in region AF3、F7、F3、P7、F8、F4、AF4 (p<0.05); the D;2 data of the AF3、F3、Fc5、T7、P7、F8 、F4、AF4 are markedly decline (p<0.05). There are no significant change in SAS、ApEn and D;2 of the non-acupuncture group. The results proved that TEAS Neiguan point can decrease anxiety, reduce the complexity of each brain region, the change mainly occur in bilateral frontal regions and bilateral temporal regions.

Key words： metrology EEG signal acupoint of Neiguan anxiety transcutaneous electrical acupoint stimulation approximate entropy correlation dimension

收稿日期: 2020-03-20 发布日期: 2022-01-06

PACS:

TB99

基金资助:燕山大学博士基金(BL17026)

作者简介: 樊凤杰(1977-),女,河北秦皇岛人,燕山大学副教授,博士,主要从事数据挖掘、中医药大数据知识发现及模式识别研究。Email: ffjmz@126.com

引用本文:

樊凤杰, 白洋, 纪会芳. 基于脑电非线性动力学特征探究TEAS内关穴对焦虑的影响[J]. 计量学报, 2022, 43(1): 133-139.
FAN Feng-jie, BAI Yang, JI Hui-fang. Explore the Influence of Transcutaneous Electrical Acupoint Stimulation Neiguan Point on Anxiety Based on Electroencephalogram Nonlinear Dynamic Analysis Method. Acta Metrologica Sinica, 2022, 43(1): 133-139.

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