高效液相色谱法测定化妆品中防晒剂奥克立林含量的不确定度评定

doi:10.3969/j.issn.1000-1158.2020.12.20

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摘要通过对化妆品能力验证样品中奥克立林含量检测的不确定度评定,分析影响防晒剂定量检测的相关因素。根据《化妆品安全技术规范》(2015年版)中15种防晒剂的高效液相色谱测定法,按照JJF 1135-2005《化学分析测量不确定度评定》和JJF 1059.1-2012《测量不确定度评定与表示》中的有关规定,建立测定奥克立林的不确定度数学模型,并对不确定度来源进行分析和评定。结果表明,当化妆品中奥克立林含量为0.843%时,拓展不确定度为0.026%(k=2)。不确定度的主要来源为标准溶液的配制及工作曲线的拟合。

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	邸铮
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	张蓉
	邬国庆

关键词 ：计量学, 奥克立林, 化妆品, 防晒剂, 高效液相色谱法, 不确定度

Abstract：The uncertainty of content detection of Octocrilene derivatives as sunscreen agent in cosmetics capability test sample was analyzed and related factors affecting the quantitative detection of sunscreen agent were analyzed. According to the high performance liquid chromatography for the determination of 15 sunscreen agents in Safety and Technical Standards for Cosmetics (2015 Edition), in accordance with JJF 1135-2005 Evaluation of Uncertainty in Chemical Analysis Measurement and JJF 1059.1-2012 Evaluation and Expression of Uncertainty in Measurement, a mathematical model for the determination of Octocrilene was established, and the source of uncertainty was analyzed and evaluated. The results showed that the content of Octocrilene in cosmetics was 0.843% and the relative expanded uncertainty of measurement result was 0.026% (k=2). The main uncertainty came from the configuration of standard solution and the fitting of calibration curve.

Key words： metrology Octocrilene cosmetics sunscreen agent high performance liquid chromatography uncertainty

收稿日期: 2019-02-12 发布日期: 2020-12-08

PACS:

TB99

通讯作者: 周荔(1965-),上海人,北京市药品检验所副主任药师,主要研究方向为实验室质量管理。Email: zb@bidc.org.cn E-mail: zb@bidc.org.cn

作者简介: 邸铮(1981-),河北唐山人,北京市药品检验所高级工程师, 主要研究方向为保健食品、化妆品检验与技术研究。Email: dizheng_bidc@163.com

引用本文:

邸铮,贾伯阳,周荔,王颖,左雪,张蓉,邬国庆. 高效液相色谱法测定化妆品中防晒剂奥克立林含量的不确定度评定[J]. 计量学报, 2020, 41(12): 1570-1575.
DI Zheng,JIA Bo-yang,ZHOU Li,WANG Ying,ZUO Xue,ZHANG Rong,WU Guo-qing. Uncertainty Evaluation for Determination of Octocrilene Derivatives as Sunscreen Agent in Cosmetics by High Performance Liquid Chromatography. Acta Metrologica Sinica, 2020, 41(12): 1570-1575.

链接本文:

http://jlxb.china-csm.org:81/Jwk_jlxb/CN/10.3969/j.issn.1000-1158.2020.12.20 或 http://jlxb.china-csm.org:81/Jwk_jlxb/CN/Y2020/V41/I12/1570

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