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Research Progress on the Detection Methods of Guanidinoacetic Acid and Creatine in Biological Samples |
LIU Ruo-yi1,XIE Jie2,QIAO Xiao-ting2,JIANG You2,HUANG Ze-jian2,DAI Xin-hua2,FANG Xiang2,YE Zi-hong1 |
1. College of Life Sciences, China Jiliang University, Hangzhou,Zhejiang 310018, China
2. Technology Innovation Center of Mass Spectrum for State Market Regulation,Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China |
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Abstract Guanidineacetic acid (GAA) and creatine (CRE), as endogenous substances of human, themselves and their related metabolites are responsible for important physiological functions, and their content and composition have an impact on human tissues and organs. GAA is the precursor of CRE, and CRE can combine with adenosine triphosphate under the action of creatine kinase to form creatine phosphate, which is the material basis for energy storage and utilization in human body. In addition, GAA and CRE are also related to the occurrence and progression of many genetic metabolic diseases, and their rapid detection is essential for the early detection and treatment of such diseases. The currently known diseases correlated with GAA and CRE and their treatment methods are reviewed systematically. The modern detection methods of GAA and CRE in biological samples are also summarized and reviewed, and their possible developmental trends in the future are prospected.
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Received: 27 December 2021
Published: 10 October 2023
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