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| Current Progress on Clinical Application and Quantitative Methods of Insulin-like Growth Factor-1 |
| ZHAO Xu,JIN You-xun,WANG Xian-xia,WU Li-qing,LIU Ya-hui |
| Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China |
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Abstract Insulin-like growth factor-1 (IGF-1) is a peptide hormone composed of 70 amino acids. Clinical studies have found that IGF-1 was closely related to endocrine diseases, cardio-cerebrovascular diseases, cancer tumors, diseases related to brain and nervous system, skin diseases, liver diseases and other diseases. IGF-1 was also found to play an important role in research of COVID-19. Therefore, the changes of serum IGF-1 content can be accurately detected as one of the auxiliary diagnostic indicators of related diseases. At present, the clinical detection methods for IGF-1 mainly include immunological analysis methods based on antigen-antibody specific binding and analysis methods based on mass spectrometry. These methods have different detection characteristics and different measurement accuracy. The relevant research progress of IGF-1 is reviewed, the functional role of IGF-1 in clinical detection and application are summarized, and the characteristics and application scenarios of its detection methods are discussed, the suggestions for further improving the detection ability of IGF-1 are also put forward.
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Received: 21 March 2022
Published: 08 March 2023
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2023, Vol. 44 
