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Uncertainty Evaluation for Determination of Octocrilene Derivatives as Sunscreen Agent in Cosmetics by High Performance Liquid Chromatography |
DI Zheng,JIA Bo-yang,ZHOU Li,WANG Ying,ZUO Xue,ZHANG Rong,WU Guo-qing |
Beijing Institute for Drug Control, Beijing 102206, China |
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Abstract The uncertainty of content detection of Octocrilene derivatives as sunscreen agent in cosmetics capability test sample was analyzed and related factors affecting the quantitative detection of sunscreen agent were analyzed. According to the high performance liquid chromatography for the determination of 15 sunscreen agents in Safety and Technical Standards for Cosmetics (2015 Edition), in accordance with JJF 1135-2005 Evaluation of Uncertainty in Chemical Analysis Measurement and JJF 1059.1-2012 Evaluation and Expression of Uncertainty in Measurement, a mathematical model for the determination of Octocrilene was established, and the source of uncertainty was analyzed and evaluated. The results showed that the content of Octocrilene in cosmetics was 0.843% and the relative expanded uncertainty of measurement result was 0.026% (k=2). The main uncertainty came from the configuration of standard solution and the fitting of calibration curve.
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Received: 12 February 2019
Published: 08 December 2020
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