液相色谱串联质谱法测定鸡蛋中利巴韦林及其代谢物总残留的不确定度评定

doi:10.3969/j.issn.1000-1158.2021.09.21

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Abstract In order to improve the accuracy of egg safety inspections test results, the uncertainty determination of total residues of ribavirin and its metabolites in eggs was evaluated by LC-MS/MS. According to the method of national standard SN/T 4519—2016 "Determination of ribavirin residue in foodstuffs of animal origin for export LC-MS/MS methods", the whole experimental process was evaluated. The main sources of uncertainty in evaluation process were the measurement repeatability, recovery rate, the weighting of sample, dilution and constant volume in sample pretreatment, preparation of standard solution, the standard curve fitting process and instrumental analysis. The extended uncertainty was 0.88μg/kg(k=2) when the total residues of ribavirin and its metabolites in eggs was 9.94μg/kg, the standard curve fitting process contributed the most to the uncertainty of measurement result.

Key words： metrology ribavirin LC-MS/MS uncertainty egg safety inspections

Received: 23 August 2020 Published: 24 September 2021

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TB99

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	Articles by authors
	LI De-heng
	LU Jing-fang
	ZENG Jin-lin
	YIN Dan-han
	LI Gao-tian

Cite this article:

LI De-heng,LU Jing-fang,ZENG Jin-lin, et al. Evaluation of Uncertainty in Determination of Total Residues of Ribavirin and its Metabolites in Eggs by LC-MS/MS[J]. Acta Metrologica Sinica, 2021, 42(9): 1250-1256.

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http://jlxb.china-csm.org:81/Jwk_jlxb/EN/10.3969/j.issn.1000-1158.2021.09.21 OR http://jlxb.china-csm.org:81/Jwk_jlxb/EN/Y2021/V42/I9/1250

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