Study on the Time-dependent Change of Attenuation Coefficient of Ultrasound Contrast Agent
LAN Qing1,2,WANG Yue-bing1,CAO Yong-gang1,CHEN Qian1
1. College of Metrology & Measurement Engineering, China Jiliang University, Hangzhou, Zhejiang 310018, China
2. Zhejiang Province Institute of Metrology, Hangzhou, Zhejiang 310018, China
Abstract To study the influence of microbubble type ultrasound contrast agent (UCA) on the attenuation of acoustic propagation, based on the theoretical model of bubble dynamics to calculate the attenuation of acoustic propagation due to changes in microscopic particle size, and the analytical expression of the attenuation coefficient of the UCA with time variation was deduced. Moreover, an experimental system was built to measure the attenuation coefficient of the UCA. Experimental results verified the validity of the theoretical model and the exponential decay law of the attenuation coefficient of the UCA over time. This study provides a basis for reducing the propagation attenuation and distortion of ultrasound waves, making the UCA are effectively used in the field of ultrasound medicine.
LAN Qing,WANG Yue-bing,CAO Yong-gang, et al. Study on the Time-dependent Change of Attenuation Coefficient of Ultrasound Contrast Agent[J]. Acta Metrologica Sinica, 2018, 39(5): 702-707.
2018, Vol. 39 
