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| Development and Certification of 2.3.4-trichloroanisoles Certified Reference Material |
| MA Kang1,ZHANG Jin-na2,WANG Hai-feng1,ZHAO Min1,HE Ya-juan1 |
1.National Institute of Metrology, Beijing 100013, China
2.University of Science and Technology Beijing, Beijing 100083, China |
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Abstract A method for development and certification of certified reference material of 2,3,4-trichloroanisoles is presented.According to analysis procedure of homogeneity, 11 bottles of sample are taken from 500 bottles at random, and the result is validated by F-test and T-test statistical methods. The stability inspection is carried on short-term(1 month) and long-term(12 months), the result indicated that the period for 2,3,4-trichloroanisoles of storage is 12 months at 20℃.The purity of 2,3,4-trichloroanisoles are determined by two methods of different principles, which are high performance liquid chromatography method and differential scanning calorimetry method.The qualitative analysis of main impurity is determined with standard addition by liquid chromatography with photo-diode array and the impurity is 2,3,6-trichloroanisoles; The content of water in 2,3,4-trichloroanisoles is measured by Karl-Fischer titrator with drying oven. The uncertainty of HPLC and DSC methods are respectively evaluated. The certified result is 99.56% and expanded uncertainty is 0.40%（k=2）.
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2012, Vol. 33 
