Study on the Effects of rTMS Combined with Exercise Tasks on Brain Function in Stroke Patients Based on Microstate Analysis

FENG Jiawei; FU Lingdi; LI Shixing; HAO Man; LIANG Zhenhu; YIN Liyong

doi:10.3969/j.issn.1000-1158.2026.04.20

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Acta Metrologica Sinica ›› 2026, Vol. 47 ›› Issue (4) : 622-632. DOI: 10.3969/j.issn.1000-1158.2026.04.20

Study on the Effects of rTMS Combined with Exercise Tasks on Brain Function in Stroke Patients Based on Microstate Analysis

FENG Jiawei ¹^,² ,
FU Lingdi ¹^,² ,
LI Shixing ⁴ ,
HAO Man ¹^,² ,
LIANG Zhenhu ¹^,² ,
YIN Liyong ³^,⁴

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Abstract

Repetitive transcranial magnetic stimulation （rTMS） generates induced currents through a time-varying magnetic field， which can regulate the neural excitability of post stroke movement disorder （PSMD） patients. The study recruited 38 participants， including 20 healthy participants and 18 stroke patients. Using rTMS stimulation of the primary motor cortex （M1） combined with motor task intervention， the impact on brain function was explored through electroencephalography （EEG） technology combined with relative power spectrum and microstate analysis.The results showed that after intervention， the behavioral scores of PSMD patients significantly increased （P<0.05）， and the relative power of theta and gamma bands near the C3 electrode in the M1 region significantly decreased （P<0.05）， approaching a healthy level. The parameters of microstate C increased significantly （P<0.05）， while those of microstate E decreased significantly （P<0.05）. High frequency band relative power and microstate C can serve as biomarkers for rTMS intervention， providing a new perspective for understanding the neural mechanisms by which rTMS improves motor function in stroke patients.

Key words

repetitive transcranial magnetic stimulation / electroencephalography / relative power spectrum / microstate analysis / stroke

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FENG Jiawei , FU Lingdi , LI Shixing , et al . Study on the Effects of rTMS Combined with Exercise Tasks on Brain Function in Stroke Patients Based on Microstate Analysis[J]. Acta Metrologica Sinica. 2026, 47(4): 622-632 https://doi.org/10.3969/j.issn.1000-1158.2026.04.20

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