Experimental Design for Measuring Dynamic Attenuation Coefficient of Layered Bio-tissue and Research on Thermal Damage Prediction

CHEN Fei; SHI Wanting; ZHAO Peng; SHEN Chao

doi:10.3969/j.issn.1000-1158.2026.04.19

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Acta Metrologica Sinica ›› 2026, Vol. 47 ›› Issue (4) : 616-621. DOI: 10.3969/j.issn.1000-1158.2026.04.19

Experimental Design for Measuring Dynamic Attenuation Coefficient of Layered Bio-tissue and Research on Thermal Damage Prediction

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Abstract

In high intensity focused ultrasound（HIFU） tumor treatment， accurate prediction of thermal damage results is necessary.Focused ultrasound is used to heat the sample tissue， and ‘the finite amplitude insertion-substitution method’ was used to measure the sound velocity and thickness of porcine fat， muscle， and liver， and to measure the attenuation coefficient of isolated tissues during temperature change. The fitting formulas of attenuation coefficient dependent on the temperature of three tissues at a frequency of 1 MHz are proposed， respectively. A multi-physics coupling model of nonlinear acoustic propagation and biological tissue heat transfer is established by using COMSOL， and the influence of dynamic attenuation coefficient on the prediction results of thermal damage is analyzed. The experimental results show that the attenuation coefficient of the ex vivo tissues has a strong dependence on temperature， and presents different changing trends. The simulation results show that the dynamic attenuation coefficient will lead to higher temperature rise and larger thermal damage area during HIFU treatment. The research can be used to guide clinicians in optimizing HIFU treatment plans and achieving precise treatment.

Key words

acoustic parameter measurement / high intensity focused ultrasound / dynamic attenuation coefficient / the finite amplitude insertion-substitution method / multi-physics coupling / thermal damage

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CHEN Fei , SHI Wanting , ZHAO Peng , et al. Experimental Design for Measuring Dynamic Attenuation Coefficient of Layered Bio-tissue and Research on Thermal Damage Prediction[J]. Acta Metrologica Sinica. 2026, 47(4): 616-621 https://doi.org/10.3969/j.issn.1000-1158.2026.04.19

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