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| Uncertainty Evaluation in Determination of Acrylamide Residues in Cosmetics by UPLC-MS/MS |
| CAO Hai-rong1,XUE Xiao-kang2,LI Xiao-yu2 |
1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China
2. Shanghai Research Institute of Chemical Industry Co.,Ltd, Shanghai 200062, China |
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Abstract The content of acrylamide in cosmetics was determined by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC MS / MS), and the uncertainty was evaluated. According to JJF 1059.1—2012 “Evaluation and Expression of Uncertainty in Measurement”, a metrological model for determination of acrylamide residues in cosmetics was established. And each component of uncertainty in the whole measuring process was analyzed and quantified. The combined uncertainty in the determination of acrylamide in cosmetics was 0.033mg/kg and the expanded uncertainty was 0.066mg/kg. The content of acrylamide in cosmetics was (0.502±0.066)mg/kg (k=2, confidence interval P=95%). The uncertainty of the method was mainly caused by standard solution preparation and calibration fitting.
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Received: 24 April 2019
Published: 20 August 2021
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［1］陈东洋, 张昊, 冯家力, 等. 饮用水中丙烯酰胺的测定及不确定度评定［J］. 职业与健康, 2018, 34 (22): 45-49.
Chen D Y, Zhang H, Feng J L, et al. Determination of acrylamide in drinking water and uncertainty evaluation ［J］. Occupation and Health, 2018, 34 (22): 45-49.
［2］Tae H K, Soyoung S, Kyu B K, et al. Determination of acrylamide and glycidamide in various biological ma-trices by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study ［J］. Talanta, 2015, 131: 46-54.
［3］郑丽敏. 溴化衍生-气相色谱法测丙烯酰胺含量的不确定度评定 ［J］. 广州化工, 2018, 46 (15): 141-143.
Zheng L M. Uncertainty evaluation of acrylamide content assaying by brominating derivation-gas chromatography ［J］. Guangzhou Chemical Industry, 2018, 46 (15): 141-143.
［4］林金美. 纺织品中丙烯酰胺含量测定的不确定度评定 ［J］. 广州化工, 2015,43(10): 134-136.
Lin J M. Evaluation of uncertainty in determination of acrylamide content in Textiles ［J］. Guangzhou Chemical Industry, 2015, 43(10): 134-136.
［5］Gottschalck T E, Mcewen G N. International cosmetic ingredient dictionary and handbook ［M］. Washington D C: Cosmetic, Toiletry and Fragrance Association (CTFA), 2002.
［6］冯岸红, 幸苑娜, 叶淋泉, 等. 超高效液相色谱-串联质谱法测定化妆品中的丙烯酰胺残留 ［J］. 理化检验, 2016, 52 (8): 941-946.
Feng A H, Xing Y N, Ye L Q, et al. Determination of acrylamide residues in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry［J］. Physico-Chemistry & Tech Chemistry, 2016, 52 (8): 941- 946.
［7］国家食品药品监督管理总局. 化妆品安全技术规范 ［S］. 2016.
［8］范巧成, 匡荣, 邢成岗, 等. 试论测量不确定度与误差理论的关系 ［J］. 计量学报, 2017, 38 (3): 380-384.
Fan Q C, Kuang R, Xing C G, et al. On the relationship between measurement uncertainty and error theory ［J］. Acta Metrologica Sinica, 2017, 38 (3): 380-384.
［9］赵飞, 王苗苗, 贾宏新. 高效液相色谱法测定糖果中苯甲酸含量的测量不确定度评定 ［J］. 计量技术, 2018,(5): 28 -31.
［10］马康, 李小佳, 崔萌萌, 等. 高效液相色谱法测定葡萄酒中苋菜红的不确定度评定 ［J］. 计量学报, 2015, 36 (1): 102-106.
Ma K, Li X J, Cui M M, et al. Uncertainty evaluation of determination of amaranthus red in wine by high performance liquid chromatography［J］.Acta Metrologica Sinica, 2015, 36 (1): 102-106.
［11］Rouvim K. Evaluation of the measurement uncertainty: Some common mistakes with a focus on the uncertainty from linear calibration［J］. Journal of Chromatography A, 2017, 1499: 226-229.
［12］Mi J L, Jeong M L, Sungjin K, et al. Simultaneous analysis and measurement of uncertainty estimation of six isoflavones in Cheonggukjang by liquid chromatography electrospray tandem mass spectrometry ［J］. Food Chemistry, 2019, 289: 139-144.
［13］Basfar A A, Moftah B, Lotfy S, et al. Evaluations of N-(Isobutoxymethyl) acrylamide gel dosimeter by NMR technique for radiotherapy and uncertainty in dose measurements ［J］. Applied Radiation and Isotopes, 2019, 148: 240-245.
［14］国家质量监督检验检疫总局. JJF 1059. 1—2012测量不确定度评定与表示 ［S］. 2012.
［15］张莉丽. 高效液相色谱法测定葡萄酒中柠檬黄、 苋菜红的不确定度分析 ［J］. 计量与测试技术, 2017, 44 (3): 110-111.
Zhang L L. Uncertainty analysis of determination of lemon yellow, amaranth in wine by high performance liquid chromatography method ［J］. Metrology and Measurement Technique, 2017, 44 (3): 110-111.
［16］王涛. 化妆品中维生素D2、 维生素D3含量的测量不确定度评定 ［J］. 计量学报, 2019, 40 (4): 728-735.
Wang T. Evaluation of Measurement Uncertainty in the Determination of Vitamin D2 and Vitamin D3 in Cos-metics［J］. Acta Metrologica Sinica, 2019, 40 (4): 728-735.
［17］贾未鸣,高旭锋,凌凤香,等. 微晶蜡含油量不确定性评估 ［J］. 计量学报, 2020, 41 (7): 886-890.
Jia W M, Gao X F, Ling F X, et al. Uncertainty Evaluation for the Oil Content of Microcrystalline Wax ［J］. Acta Metrologica Sinica, 2020, 41(7): 886-890. |
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2021, Vol. 42 
