|
|
|
| Uncertainty Evaluation for Determination of Octocrilene Derivatives as Sunscreen Agent in Cosmetics by High Performance Liquid Chromatography |
| DI Zheng,JIA Bo-yang,ZHOU Li,WANG Ying,ZUO Xue,ZHANG Rong,WU Guo-qing |
| Beijing Institute for Drug Control, Beijing 102206, China |
|
|
|
|
Abstract The uncertainty of content detection of Octocrilene derivatives as sunscreen agent in cosmetics capability test sample was analyzed and related factors affecting the quantitative detection of sunscreen agent were analyzed. According to the high performance liquid chromatography for the determination of 15 sunscreen agents in Safety and Technical Standards for Cosmetics (2015 Edition), in accordance with JJF 1135-2005 Evaluation of Uncertainty in Chemical Analysis Measurement and JJF 1059.1-2012 Evaluation and Expression of Uncertainty in Measurement, a mathematical model for the determination of Octocrilene was established, and the source of uncertainty was analyzed and evaluated. The results showed that the content of Octocrilene in cosmetics was 0.843% and the relative expanded uncertainty of measurement result was 0.026% (k=2). The main uncertainty came from the configuration of standard solution and the fitting of calibration curve.
|
|
Received: 12 February 2019
Published: 08 December 2020
|
|
|
|
|
|
［1］国家食品药品监督管理总局. 化妆品安全技术规范(2015年版)［S］. 2015.
［2］朱美霞, 张瑞波, 辛春伟. 紫外线吸收剂奥克立林衍生物的合成与性能研究［J］. 天津理工大学学报, 2015, 31(3): 55-58.
Zhu M X, Zhang R B, Xin C W. Synthesis and characterization of Octocrilene derivatives as UV absorber［J］. Journal of Tianjin University of Technology, 2015, 31(3): 55-58.
［3］姚孝元. 我国防晒化妆品中紫外线吸收剂分类和紫外吸收光谱［J］. 中国卫生检验杂志, 2005, 15(2): 236-240.
Yao X Y. Category and UV absorption spectrum of UV filters in sunscreen cosmetics in China［J］. Chinese Journal of Health Laboratory Technology, 2005, 15(2): 236-240.
［4］高立雪, 张丽霞. 防晒化妆品中防晒剂使用量分析［J］. 中国公共卫生, 2011, 27(6): 785-786.
Gao L X, Zhang L X. Contents of sunscreen agents in cosmetic products［J］. Chinese Journal of Public Health, 2011, 27(6): 785-786.
［5］倪育才. 实用测量不确定度评定［M］. 北京: 中国计量出版社, 2004.
［6］JJF 1059. 1-2012 测量不确定度评定与标示［S］. 2012.
［7］中国实验室国家认可委员会. 化学分析中不确定度的评估指南［M］. 北京: 中国计量出版社, 2002.
［8］JJF 1135-2005 化学分析测量不确定度评定［S］. 2005.
［9］王涛,刘鹏鸣,杜晖,等. 化妆品中维生素D2、维生素D3含量的测量不确定度评定［J］.计量学报, 2019, 40(4): 728-735.
Wang T, Liu P M, Du H, et al. Evaluation of Measurement Uncertainty in the Determination of Vitamin D2 and Vitamin D3 in Cosmetics［J］. Acta Metrologica Sinica, 2019, 40(4): 728-735.
［10］JJG 196-2006, 常用玻璃量器［S］. 2006.
［11］GB/T 12808-2015 实验室玻璃仪器 单标线吸量管［S］. 2015.
［12］GB 12807-1991 实验室玻璃仪器 分度吸量管［S］. 1991.
［13］GB/T 12806-2011 实验室玻璃仪器 单标线容量瓶［S］. 2011.
［14］徐娜. 防晒化妆品中紫外吸收剂的分析及其光稳定性研究［D］. 杭州:浙江工业大学, 2012. |
|
|
|
2020, Vol. 41 
