|
|
|
| New Method for Blood Type Detection Based on Bioelectrical Impedance Analysis Technology and its System Implementation |
| CHEN Li-li1,2, LIAO Qiang1,2, HU Xue3, ZHANG Guo-zheng3 |
1.State Key Lab of Mechanical Transmission, Chongqing 400030, China;
2. College of Mechanical Engineering, Chongqing University, Chongqing 400030, China;
3. Blood Transfusion Department, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China |
|
|
|
|
Abstract A new method for blood type detection and a new automated blood typing system are developed. In the system, the combined use of the AD9850 chip and MCU are employed to realize the DDS technique and produce excitation signal. Then an elliptic filter is designed to eliminate the signal interference, and an amplitude stabilized circuit is designed to stabilize the amplitude of the signal output by using an AD8370 chip, which is a low-cost variable gain amplifier. The amplitude and phase measurement chip AD8302 is adopted to extract the impedance information. Based on neural network recognition model, a new method is designed to determine the degree of agglutination in red blood cell suspension. The use of this method combined with the discriminant rule could successfully identify the blood type. Contrastive test is carried out and the new system showed high measurement accuracy and good stability. This system could better distinguish the different intensity of agglutination in red blood cell, and identified ABO and Rh blood type correctly in normal samples. The self-developed new automated blood typing system is in better agreement with clinical requirements.
|
|
|
|
|
|
［1］ Sandler S G, Langeberg A, Avery N, et al. A fully automated blood typing system for hospital transfusion services ［J］. Transfusion, 2000, 40(2):201-207.
［2］ Ferraz A, Carvalho V, Soares F. Development of a human blood type detection automatic system ［J］.Procedia Engineering, 2010, 5: 496-499.
［3］ Dada A, Beck D, Schmitz G. Automation and Data Processing in Blood Banking Using the Ortho AutoVue Innova System［J］. Transfusion Medicine Hemotherapy, 2007,34(5): 341–346.
［4］ 董秀珍.生物电阻抗技术研究进展［J］. 中国医学物理学杂志,2004,21(6):311-320.
［5］ Baskurt O K, Uyuklu M, Meiselman H J. Time course of electrical impedance during red blood cell aggregation in a glass tube: comparison with light transmittance［J］. IEEE Trans Biomed Eng,2010,57(4):969-978. |
|
|
|
2014, Vol. 35 
