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计量学报  2023, Vol. 44 Issue (4): 657-663    DOI: 10.3969/j.issn.1000-1158.2023.04.25
  电离辐射、标准物质与生物计量 本期目录 | 过刊浏览 | 高级检索 |
基于脉搏心电信号碰撞熵的血糖控制状态检测研究
肖明霞1,2,鲁昌华1,塔娜2,王涛1
1.合肥工业大学 计算机与信息学院,安徽 合肥 230601
2.北方民族大学 电气信息工程学院,宁夏 银川 750021
Research of Blood Glucose Control State Detection Based on Percussion Entropy
XIAO Ming-xia1,2,LU Chang-hua1,NA Ta2,WANG Tao1
1. School of Computer and Information, Hefei University of Technology, Hefei, Anhui 230601, China
2. School of Electrical and Information Engineering, North Minzu University, Yinchuan, Ningxia 750021, China
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摘要 针对现有糖尿病患者血糖控制状态分析模型中存在的局限性,提出了一种基于碰撞熵(PEn)的血糖控制状态分析算法。该方法采用非侵入式采集人体脉搏波与心电信号,提取脉搏波信号幅值特征和心电信号R波周期时间间隔特征,形成2个时间同步的数值序列。比较2个序列的变化趋势,计算得到脉搏波和心电信号的碰撞熵,最后进行血糖控制状态检测。实验结果表明,PEn在健康人群和血糖控制良好的糖尿病患者间的差异性为p=0.014,在血糖控制良好糖尿病患者和血糖控制不佳糖尿病患者间为p=0.002。从糖化血红蛋白(HbA1c)的影响角度分析,PEn指标受其影响,比脉搏波最大能量瞬时频率fEmax_RF指标高30.5%,反映出PEn不仅可用于反映糖尿病患病情况,而且在血糖控制情况方面表现出良好差异性。
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肖明霞
鲁昌华
塔娜
王涛
关键词 计量学血糖控制碰撞熵心电信号脉搏信号    
Abstract:Aiming at the limitations of existing models of blood glucose control state analysis, an algorithm of blood glucose control state analysis based on percussion entropy (PEn) was proposed.The human pulse wave and ECG signal were collected non-invasively. The amplitude characteristics of the pulse wave signal and the time interval characteristics of the R wave cycle of the ECG signal were extracted to form two time-synchronized numerical sequences. Compared the change trends of the two sequences, calculate the collision entropy of the pulse wave and the ECG signal, and finally detect the blood glucose control status. The results showed that the difference of PEn between healthy and well-controlled diabetic patients was p=0.014, while that between well-controlled and poorly-controlled diabetic patients was p=0.002.From the impact of HbA1c on the two indicators, the PEn index was 30.5% higher than the index of fEmax_RF.PEn can not only been used to reflect the prevalence of diabetes mellitus, but also showed good differences in glycemic control.
Key wordsmetrology;glucose control;percussion entropy;ECG signal    pulse wave
收稿日期: 2022-11-03      发布日期: 2023-04-18
PACS:  TB99  
基金资助:宁夏回族自治区自然科学基金项目(2020AAC03220)
作者简介: 肖明霞(1978-),女,黑龙江泰来人,北方民族大学副教授,主要研究领域为机器学习、生物医学信号的检测与分析。Email:xiao_mx@nmu.edu.cn
引用本文:   
肖明霞,鲁昌华,塔娜,王涛. 基于脉搏心电信号碰撞熵的血糖控制状态检测研究[J]. 计量学报, 2023, 44(4): 657-663.
XIAO Ming-xia,LU Chang-hua,NA Ta,WANG Tao. Research of Blood Glucose Control State Detection Based on Percussion Entropy. Acta Metrologica Sinica, 2023, 44(4): 657-663.
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